BDBM50009859 (+-)-2-(p-isobutylphenyl)propionic acid::(+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid::(+-)-ibuprofen::(+-)-p-isobutylhydratropic acid::(4-isobutylphenyl)-alpha-methylacetic acid::(RS)-ibuprofen::2-(4-isobutylphenyl)propanoic acid::2-[4-(2-methylpropyl)phenyl]propanoic acid::4-isobutylhydratropic acid::Advil::Brufen::CHEMBL521::IBUPROFEN LYSINE::Ibuprofen::Ibuprofen (1)::Motrin::alpha-(4-isobutylphenyl)propionic acid::alpha-(p-isobutylphenyl)propionic acid
SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
InChI Key InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 54 hits for monomerid = 50009859
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
3D Structure (crystal)TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of sheep placental cotyledons COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 8.00E+3nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Concentration (in microM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver est...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro inhibitory concentration of the compound against COX-2 enzymeMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of bovine COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human recombinant COX2 after 5 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human recombinant COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysisMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 8.00E+3nMAssay Description:Tested for inhibitory activity against Prostaglandin G/H synthase 2 from humanMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.66E+5nMAssay Description:Inhibitory concentration against Prostaglandin G/H synthase 2 from sheep placenta at 100 uMMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human COX2 pre-incubated for 10 mins before substrate addition by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of COX2 in human whole blood after 15 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.03E+6nMAssay Description:Inhibition of COX2-catalyzed prostaglandin biosynthesis after 10 mins of preincubationMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX-2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 3.70E+5nMAssay Description:Inhibition of sheep placental cotyledons COX2 assessed as PGE2 productionMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.03E+6nMAssay Description:Inhibition of sheep placental cotyledons COX2 assessed as PGE2 production preincubated for 10 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human COX2 expressed in baculovirus systemMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant COX-2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin produc...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGE2 formation pre-incubated for 5 mins before arachidonic acid addition and measured a...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human COX-2 preincubated for 15 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGE2 production using arachidonic acid substrate by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mi...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant COX2 expressed in Sf9 cells using arachidonic acid and ADHP incubated for 5 mins by fluorimetryMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in PGE2 production using 10 uM arachidonic acid as substrate preincubated with enzyme for...More data for this Ligand-Target Pair